About the lab

Welcome to the Misono lab. Our lab is a part of the Graduate School of Brain Science at Doshisha University, Kyoto, Japan, as the section of Ion Channel Pathophysiology. The lab launched in 2006 at the University of Maryland and moved to Kyoto in April 2012.



Our research focuses on the Neurobiology of protein regulation, particularly ion channels and Alzheimer’s tau protein. Ion channels are the engine that generates electrical signals for neurons to transmit signals and to compute. We aim to understand how hundreds of different ion channels work in individual neurons, in neural network, and in animals.
   At the moment, we particularly focus on studying the roles of tau protein in normal and in Alzheimer’s disease.


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Selected Publications

Yonemura Y, Sakai Y, Nakata R, Hagita-Tatsumoto A, Miyasaka T, Misonou H. (2023) Active Transport by Cytoplasmic Dynein Maintains the Localization of MAP2 in Developing Neurons. Biorxiv (preprint).

Torii T., Miyamoto Y., Nakata R., Higashi Y., Shinmyo Y., Kawasahki H.,  Miyasaka T., and Misonou H. (2022) Identification of Tau Protein as a Novel Marker for Maturation and Pathological Changes of Oligodendrocytes. Glia 71, 1002-1017.

Iwata M., Watanabe S., Yamane, Y., Miyasaka T., and  Misonou H. (2019) Regulatory mechanisms for the axonal localization of tau protein in neurons. Molecular Biology of the Cell 30, 2441-2457.  PDF

Kubo A., Ueda S., Yamane A., Wada-Kakuda S., Narita M.,  Matsuyama M.,  Nomori A.,  Takashima A.,  Kato T.,  Onodera O.,  Goto M.,  M.,  Tomiyama T.,  Mori H.,  Murayama S.,  Ihara Y.,  Misonou H., and  Miyasaka T. (2019) Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain. Journal of Neuroscience 39, 6781-6797.  PDF

Hirono, M., Watanabe, S., Karube, F., Fujiyama, F., Kawahara, S., Nagao, S., Yanagawa, Y., and Misonou, H. (2018) Perineuronal nets in the deep cerebellar nuclei regulate GABAergic transmission and delay eyeblink conditioning. Journal of Neuroscience 38, 6130-6144.  PDF

Jensen, C.S., Watanabe, S., Stas, J.I., Klaphaak, J., Yamane, A., Schmitt, N., Olesen, S.P.O., Trimmer, J.S., Rasmussen, H.B., and Misonou, H. (2017) Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Non-Conventional Secretory Pathway. Journal of Neuroscience 37, 11523-11536.  PDF

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