Our Research

How does axonal tau become accumulated in the cell body and dendrites in Alzheimer’s disease? アルツハイマー病の病因タンパク質タウはどのように神経細胞内に蓄積していくの?

Tau (shown in red) is one of the microtubule-associated proteins and specifically localized to the axon (cell body and dendrites shown in green), where it is thought to contribute to the axonal structure and protein trafficking. However, in pathological conditions, such as in Alzheimer’s disease, tau mis-localizes to dendrites and forms aggregates called the neurofibrillary tangles. We investigate the molecular mechanisms that determines the axonal localization in normal and how it is disrupted in diseases.


Back to Index